We are seeking a highly motivated postdoctoral candidate to join our cancer- immunology group. The Rufer lab focuses on investigating human CD8 T-cell responses to self-(tumor) and foreign (viral) antigens, aiming to advance our knowledge of T cell-mediated protection from human disease and to develop strategies for adoptive cell therapies using engineered or natural anti-cancer T cells. We showed that the T cell receptor (TCR)-binding avidity is a valuable indicator for evaluating antigen-specific T cell responses, serving as a potential biomarker of T cell therapeutic effectiveness (1, 2) and a key parameter in regulating T-cell clonal repertoires during latent herpes virus infection (3).

Presentation

A postdoctoral position is now available to study the key biophysical and functional determinants of anti-tumor TCRs related to clinical efficacy using high-throughput screening technologies. The objectives are to determine the characteristics that define the most suitable and safe TCR candidates for adoptive T cell therapy.

Job information

• Expected start date in position: 01.11.2025


• Activity rate: 80 to 100%


• Workplace: SE-C, Biopôle campus, Epalinges, Switzerland (Lausanne area)

What the position offers you

Join the Swiss Cancer Center at Lausanne (SCCL), a collaborative hub of cancer, genetics, and immunology research, supported by the expertise

of Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Ludwig Institute for Cancer Research (LICR), and Swiss Federal Institute of Technology of Lausanne (EPFL). Benefit from numerous core facilities and a vibrant international work setting.

Profile requirements

Candidates should hold a PhD or an MD/PhD in immunology, cancer biology or biochemistry, with a strong background in human T-cell biology. They must have solid theoretical and practical expertise in immunology or oncology, including cellular & molecular biology. Fluency in spoken and written English is prerequisite.

Your application

Applicants should send a cover letter, including a brief statement o research experience and interests (max 2 pages), their curriculum vitae and publication list, as well as the names and contact information of three references.

Please send your application to: Dr. Nathalie Rufer, e-mail: Nathalie.Rufer@unil.ch.