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10.06.2019 MOLECULAR CHATTER MAKES FOR A « HOT TUMOR »
JUNE 10, 2019, NEW YORK – A Ludwig Cancer Research study has deciphered a complex molecular conversation between cancer and immune cells that is key to orchestrating the successful invasion of tumors by T cells that kill cancer cells.
“We show that two key chemokines, CCL5 and CXCL9, are universally implicated in T cell infiltration across all solid tumors,” said George Coukos, who directs the Lausanne Branch of the Ludwig Institute for Cancer Research and led the study. “Their simultaneous presence in tumors is a key requirement for the engraftment of T cells and the establishment of a T cell-inflamed tumor, also known as a ‘hot tumor.’”